SOX9

Across TCGA pan-cancer cohorts, SOX9 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SOX9 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SOX9 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SOX9 expression acts as an unfavorable survival marker.

HNSC, KIRP, and SKCM are the cancer types where SOX9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.152	0.630	<.001	48	view →
KIRP	DFS	Median	All	0.088	0.920	<.001	45	view →
SKCM	OS	Median	All	0.230	0.781	.004	21	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SOX9–HNSC (OS)

Open the HNSC breakdown →