SOX9

Across TCGA pan-cancer cohorts, SOX9 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SOX9 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SOX9 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SOX9 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where SOX9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.607	0.874	.018	27	view →
PDAC	OS	Tertile	III,IV	0.937	0.302	.017	14	view →
GBM	OS	Tertile	All	0.535	0.244	.014	9	view →
LSCC	DFS	Quartile	All	0.167	0.889	.006	7	view →
UCEC	DFS	Median	All	1.000	0.932	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SOX9–HNSC (OS)

Open the HNSC breakdown →