SOX9

Across TCGA patient cohorts, SOX9 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,480 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOX9-associated proteins across cancer lineages are SOX6_S454, CBX8, and VPS37B. Each is linked with SOX9 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX9 versus SOX6_S454 in BRCA, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOX6_S454 →	+0.735	+1.154	.008	<.001	3	4
GBM	CBX8 →	+0.409	+0.734	.001	<.001	3	4
GBM	VPS37B →	+0.369	+0.955	<.001	<.001	3	4
GBM	ISG20 →	-0.363	-0.722	.004	<.001	3	4
LUAD	TESC →	+0.931	+1.185	<.001	<.001	3	4
GBM	TLE1_S286 →	+0.511	+0.672	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,480 associations by consensus.

SOX9 vs SOX6_S454 — BRCA

Explore this scatter interactively →