SOX9

Across TCGA patient cohorts, SOX9 protein abundance is significantly associated with the RNA expression of many other genes, with 11,882 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOX9-associated genes across cancer lineages are SOX9-AS1, LINC02097, and ZNF3. Each is linked with SOX9 in more than 8 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX9 versus SOX9-AS1 in GBM, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX9-AS1 →	+0.889	+0.715	<.001	<.001	3	9
GBM	LINC02097 →	+0.963	+0.763	<.001	<.001	3	8
OV	ZNF3 →	+0.562	+0.811	<.001	<.001	3	5
PDAC	LINC01152 →	+1.092	+0.467	<.001	<.001	3	5
BRCA	SLC16A6 →	-1.551	-0.712	<.001	<.001	3	4
GBM	IL1R1 →	-1.535	-0.534	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,882 associations by consensus.

SOX9 vs SOX9-AS1 — GBM

Explore this scatter interactively →