SOX9

Across TCGA patient cohorts, SOX9 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX9-associated genes across cancer lineages are p53, Caspase-7-cleavedD198, and HER3_pY1289. Each is linked with SOX9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by SOX9-low versus SOX9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p53 →	-0.315	-2.321	.010	.033	3	3
UCEC	Caspase-7-cleavedD198 →	+0.712	+2.720	.001	.003	3	3
COAD	HER3_pY1289 →	+0.090	+3.338	.012	.004	3	2
COAD	Bim →	-0.237	-3.000	.021	.034	3	2
UCEC	ERK2 →	+0.211	+2.700	.003	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.150	-1.807	.017	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p53 by SOX9 expression — COAD

Explore this box plot interactively →