SOX9

Across TCGA cell cohorts, SOX9 RNA expression is significantly associated with the RNA expression of many other genes, with 6,425 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SOX9-associated genes across cancer lineages are GAS6, SH3KBP1, and SH3BP4. Each is linked with SOX9 in more than 7 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX9 versus GAS6 in BONE, with a Pearson correlation of 0.42.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GAS6 →	+3.075	+2.024	.001	.004	2	8
SOFT_TISSUE	SH3KBP1 →	+1.627	+2.985	<.001	<.001	3	7
SOFT_TISSUE	SH3BP4 →	+2.070	+2.199	.001	<.001	3	6
LUNG_NSCLC_LUSC	ARHGAP26 →	+1.364	+2.090	.001	.002	2	7
BREAST	SH3TC2 →	+1.671	+1.918	<.001	<.001	3	6
BREAST	SPATS2L →	+1.947	+1.846	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,425 associations by consensus.

SOX9 vs GAS6 — BONE

Explore this scatter interactively →