SOX9

Across TCGA cell cohorts, SOX9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,576 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SOX9-associated GO terms across cancer lineages are Negative regulation of photoreceptor cell differentiation, Male sex determination, and Neural crest cell fate commitment. Each is linked with SOX9 in more than 17 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of photoreceptor cell differentiation grouped by SOX9-low versus SOX9-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of photoreceptor cell differentiation →	+1.432	+2.641	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Male sex determination →	+1.466	+2.755	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Neural crest cell fate commitment →	+1.392	+2.855	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Stem cell fate commitment →	+1.392	+2.855	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Branch elongation of an epithelium →	+1.724	+3.641	<.001	<.001	3	16
BONE	Regulation of photoreceptor cell differentiation →	+1.471	+2.927	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,576 associations by consensus.

Negative regulation of photoreceptor cell differentiation by SOX9 expression — OESOPHAGUS

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