SOX9

Across TCGA cell cohorts, SOX9 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX9-associated genes across cancer lineages are TTPA, REG3A, and GAGE12E. Each is linked with SOX9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTPA grouped by SOX9-low versus SOX9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTPA →	+0.823	+3.409	.001	.008	3	2
LUNG_NSCLC_LUSC	REG3A →	+0.696	+4.643	.002	.008	3	1
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
CNS	MTRNR2L10 →	+0.012	+5.357	<.001	.001	3	1
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	1
OVARY	RBMY1J →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

TTPA by SOX9 expression — BLOOD_Leukemia

Explore this box plot interactively →