SOX9

Across TCGA cell cohorts, SOX9 mutation is significantly associated with the mutation status of many other genes, with 3,566 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX9-associated genes across cancer lineages are SNAP91, KCNC2, and PDZRN3. Each is linked with SOX9 in more than 4 cancer types. Because this analysis shows association rather than direction, both SOX9-to-partner and partner-to-SOX9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNAP91 grouped by SOX9-low versus SOX9-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX9→partner) and Y-score (partner→SOX9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SNAP91 →	+4.584	+4.584	.007	.007	1	5
CNS	KCNC2 →	+4.614	+4.614	.006	.006	1	5
SKIN	PDZRN3 →	+4.824	+5.392	.004	.004	1	5
LARGE_INTESTINE	INSRR →	+1.893	+1.693	.003	.003	1	5
BLOOD_Leukemia	JAG2 →	+2.675	+3.080	.004	.004	1	5
BLOOD_Leukemia	ZNF777 →	+2.997	+3.697	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,566 associations by consensus.

SNAP91 by SOX9 expression — BLOOD_Lymphoma

Explore this box plot interactively →