SOX7

Across TCGA patient cohorts, SOX7 mutation is significantly associated with the RNA expression of many other genes, with 1,784 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX7-associated genes across cancer lineages are NCAPG, CDCA2, and ZNHIT3. Each is linked with SOX7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX7-to-partner and partner-to-SOX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by SOX7-low versus SOX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX7→partner) and Y-score (partner→SOX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	+0.620	+2.914	.003	.001	3	3
UCEC	CDCA2 →	+0.740	+3.721	<.001	<.001	3	3
UCEC	ZNHIT3 →	+0.341	+3.534	.009	.002	3	2
UCEC	PIGW →	+0.548	+2.470	.001	<.001	3	2
BRCA	VTRNA3-1P →	+0.666	+5.440	<.001	<.001	3	2
BRCA	OR7E162P →	+0.202	+4.539	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,784 associations by consensus.

NCAPG by SOX7 expression — UCEC

Explore this box plot interactively →