SOX7

Across TCGA cell cohorts, SOX7 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX7-associated genes across cancer lineages are GLYAT, CPLX4, and USP17L3. Each is linked with SOX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX7-to-partner and partner-to-SOX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLYAT grouped by SOX7-low versus SOX7-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX7→partner) and Y-score (partner→SOX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GLYAT →	+0.073	+3.736	<.001	.008	3	2
SOFT_TISSUE	CPLX4 →	+0.045	+3.791	<.001	.007	3	2
BLOOD_Leukemia	USP17L3 →	+0.009	+3.185	.001	.006	3	2
LARGE_INTESTINE	TAFA1 →	+0.183	+3.009	.007	.001	3	2
SOFT_TISSUE	IFNA8 →	+0.039	+4.515	<.001	<.001	3	1
SOFT_TISSUE	ADGRE3 →	+0.004	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GLYAT by SOX7 expression — SOFT_TISSUE

Explore this box plot interactively →