SOX4

Across TCGA patient cohorts, SOX4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,161 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOX4-associated genes across cancer lineages are MEX3A, VEZF1, and PACC1. Each is linked with SOX4 in more than 6 cancer types. Because this analysis shows association rather than direction, both SOX4-to-partner and partner-to-SOX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX4 versus MEX3A in GBM, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX4→partner) and Y-score (partner→SOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MEX3A →	+1.521	+1.258	<.001	<.001	3	7
HNSC	VEZF1 →	+0.870	+1.664	.004	.004	3	6
GBM	PACC1 →	+0.623	+1.071	<.001	<.001	3	6
LSCC	THOC5 →	+0.656	+0.969	<.001	<.001	3	5
LSCC	VPS72 →	+0.537	+0.819	.001	<.001	3	5
GBM	FAM200B →	+0.593	+0.987	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,161 associations by consensus.

SOX4 vs MEX3A — GBM

Explore this scatter interactively →