SOX4

Across TCGA cell cohorts, SOX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,393 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOX4-associated GO terms across cancer lineages are Noradrenergic neuron differentiation, Ascending aorta development, and Ascending aorta morphogenesis. Each is linked with SOX4 in more than 19 cancer types. Because this analysis shows association rather than direction, both SOX4-to-partner and partner-to-SOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Noradrenergic neuron differentiation grouped by SOX4-low versus SOX4-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX4→partner) and Y-score (partner→SOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Noradrenergic neuron differentiation →	+1.719	+2.168	<.001	<.001	3	20
SOFT_TISSUE	Ascending aorta development →	+1.113	+2.064	<.001	<.001	3	20
SOFT_TISSUE	Ascending aorta morphogenesis →	+1.113	+2.064	<.001	<.001	3	20
URINARY_TRACT	Pro-B cell differentiation →	+1.085	+3.798	.001	<.001	3	19
SOFT_TISSUE	Positive regulation of gamma-delta T cell differentiation →	+1.126	+1.534	<.001	<.001	3	18
SOFT_TISSUE	Positive regulation of gamma-delta T cell activation →	+1.313	+1.502	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,393 associations by consensus.

Noradrenergic neuron differentiation by SOX4 expression — KIDNEY

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