SOX4

Across TCGA cell cohorts, SOX4 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SOX4-associated genes across cancer lineages are FSHB, ANKRD60, and DAZ3. Each is linked with SOX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX4-to-partner and partner-to-SOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by SOX4-low versus SOX4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX4→partner) and Y-score (partner→SOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FSHB →	+0.032	+4.321	<.001	.009	3	2
SOFT_TISSUE	ANKRD60 →	+0.020	+5.977	<.001	.001	3	1
BLOOD_Leukemia	DAZ3 →	+0.009	+4.539	.001	.007	3	1
BLOOD_Leukemia	PRR23A →	+0.028	+5.269	.006	<.001	3	1
BLOOD_Leukemia	USP17L13 →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	USP17L17 →	+0.005	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

FSHB by SOX4 expression — CNS

Explore this box plot interactively →