SOX4

Across TCGA cell cohorts, SOX4 mutation is significantly associated with the mutation status of many other genes, with 1,152 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOX4-associated genes across cancer lineages are LMTK3, ATP8B2, and ADCY2. Each is linked with SOX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX4-to-partner and partner-to-SOX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMTK3 grouped by SOX4-low versus SOX4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX4→partner) and Y-score (partner→SOX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LMTK3 →	+2.870	+3.347	.009	.009	1	4
BLOOD_Lymphoma	ATP8B2 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Leukemia	ADCY2 →	+3.063	+3.498	.006	.006	1	3
CNS	TRIM28 →	+4.614	+4.614	.006	.006	1	3
CNS	MTSS2 →	+5.614	+5.044	.003	.003	1	3
CNS	NTRK3 →	+4.614	+4.614	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,152 associations by consensus.

LMTK3 by SOX4 expression — BLOOD_Leukemia

Explore this box plot interactively →