SOX30

Across TCGA patient cohorts, SOX30 mutation is significantly associated with the RNA expression of many other genes, with 2,953 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX30-associated genes across cancer lineages are MTND4LP20, MIR4797, and PES1. Each is linked with SOX30 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX30-to-partner and partner-to-SOX30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4LP20 grouped by SOX30-low versus SOX30-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX30→partner) and Y-score (partner→SOX30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MTND4LP20 →	+0.131	+5.148	<.001	.002	3	2
LUSC	MIR4797 →	+0.725	+3.866	<.001	.008	3	2
UCEC	PES1 →	+0.396	+1.754	.002	.001	3	2
SKCM	CRYBB2P1 →	+0.685	+3.616	<.001	.001	3	2
UCEC	HIRA →	+0.342	+1.776	.002	<.001	3	2
UCEC	TOMM22 →	+0.323	+1.776	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,953 associations by consensus.

MTND4LP20 by SOX30 expression — LUSC

Explore this box plot interactively →