SOX30

Across TCGA cell cohorts, SOX30 mutation is significantly associated with the RNA expression of many other genes, with 360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX30-associated genes across cancer lineages are TRMU, PDS5A, and USP37. Each is linked with SOX30 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX30-to-partner and partner-to-SOX30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by SOX30-low versus SOX30-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX30→partner) and Y-score (partner→SOX30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRMU →	+0.643	+3.502	<.001	.001	3	2
LARGE_INTESTINE	PDS5A →	+0.620	+3.502	<.001	.001	3	2
LARGE_INTESTINE	USP37 →	+0.653	+3.064	.002	.009	3	2
LARGE_INTESTINE	SENP3 →	+0.532	+3.502	.002	.001	3	2
LARGE_INTESTINE	PPP4R2 →	+0.471	+3.502	.006	.001	3	2
LARGE_INTESTINE	C12orf50 →	+0.098	+2.242	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 360 associations by consensus.

TRMU by SOX30 expression — LARGE_INTESTINE

Explore this box plot interactively →