SOX3

Across TCGA cell cohorts, SOX3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,089 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SOX3-associated genes across cancer lineages are BZW2, SLC17A5, and EPB41L1. Each is linked with SOX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX3-to-partner and partner-to-SOX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX3 versus BZW2 in LARGE_INTESTINE, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX3→partner) and Y-score (partner→SOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BZW2 →	+0.844	+0.538	.002	.003	3	4
LARGE_INTESTINE	SLC17A5 →	-1.001	-0.759	.002	.001	3	3
LARGE_INTESTINE	EPB41L1 →	+1.290	+0.694	.003	.005	3	3
OVARY	CEP70 →	-0.821	-1.956	.004	.002	3	3
LUNG_NSCLC_LUAD	HERC6 →	-1.319	-0.907	.001	.007	3	3
KIDNEY	PANK3 →	-1.075	-1.109	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,089 associations by consensus.

SOX3 vs BZW2 — LARGE_INTESTINE

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