SOX3

Across TCGA cell cohorts, SOX3 protein abundance is significantly associated with the go_rna of many other GO terms, with 610 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SOX3-associated GO terms across cancer lineages are DNA-templated transcription termination, Corpus callosum development, and Regulation of hydrogen peroxide metabolic process. Each is linked with SOX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX3-to-partner and partner-to-SOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription termination grouped by SOX3-low versus SOX3-high in LUNG_NSCLC_LUAD.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX3→partner) and Y-score (partner→SOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNA-templated transcription termination →	+0.078	+1.142	.001	.002	3	3
BLOOD_Lymphoma	Corpus callosum development →	-0.097	-1.058	.001	.001	3	3
BREAST	Regulation of hydrogen peroxide metabolic process →	-0.148	-0.766	.003	.003	3	3
BLOOD_Lymphoma	Tail-anchored membrane protein insertion into ER membrane →	-0.100	-1.416	<.001	<.001	3	3
BONE	Metanephric mesenchyme development →	+0.184	+0.990	.007	.004	3	3
LUNG_NSCLC_LUAD	Calcitonin gene-related peptide receptor signaling pathway →	-1.863	-1.099	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 610 associations by consensus.

DNA-templated transcription termination by SOX3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →