SOX3

Across TCGA cell cohorts, SOX3 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX3-associated genes across cancer lineages are MMP27, CRYAA, and GPR101. Each is linked with SOX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX3-to-partner and partner-to-SOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by SOX3-low versus SOX3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX3→partner) and Y-score (partner→SOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CRYAA →	+0.050	+3.705	.001	.007	3	1
BLOOD_Leukemia	GPR101 →	+0.108	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MAGEC3 →	+0.240	+3.855	.001	.007	3	1
BLOOD_Leukemia	INSM2 →	+0.395	+3.769	<.001	.008	3	1
BLOOD_Leukemia	NKX2-6 →	+0.361	+4.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

MMP27 by SOX3 expression — BLOOD_Leukemia

Explore this box plot interactively →