Across TCGA pan-cancer cohorts, SOX18 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SOX18 data layer compared with 28 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SOX18 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SOX18 expression acts as an unfavorable survival marker.

KIRP and COAD are the cancer types where SOX18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.199	0.903	<.001	15	view →
COAD	DFS	Median	All	0.194	0.688	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SOX18 tumor-vs-normal RNA expression · all SOX18 data types