SOX13

Across TCGA pan-cancer cohorts, SOX13 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SOX13 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SOX13 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SOX13 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where SOX13 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.969	0.655	<.001	50	view →
LUAD	DFS	Median	III,IV	0.554	0.977	.009	8	view →
LSCC	DFS	Median	II,III,IV	0.837	0.577	.037	4	view →
HNSC	OS	Tertile	III,IV	0.838	0.450	.025	3	view →
PDAC	OS	Median	II,III,IV	0.795	0.360	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SOX13–CCRCC (OS)

Open the CCRCC breakdown →