SOX13

Across TCGA cell cohorts, SOX13 mutation is significantly associated with the RNA expression of many other genes, with 140 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX13-associated genes across cancer lineages are TCF21, OR2T6, and SSTR4. Each is linked with SOX13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX13-to-partner and partner-to-SOX13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by SOX13-low versus SOX13-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX13→partner) and Y-score (partner→SOX13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TCF21 →	+0.024	+3.954	.005	.005	3	1
BLOOD_Lymphoma	OR2T6 →	+0.009	+4.058	<.001	.009	3	1
CNS	SSTR4 →	+0.024	+4.285	.007	.001	3	1
CNS	HMHB1 →	+0.251	+4.169	<.001	.008	3	1
CNS	CBY2 →	+0.255	+3.774	<.001	.008	3	1
CNS	MRGPRX4 →	+0.754	+3.706	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

TCF21 by SOX13 expression — BLOOD_Lymphoma

Explore this box plot interactively →