SOX12

Across TCGA patient cohorts, SOX12 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX12-associated genes across cancer lineages are Lck, Caspase-7-cleavedD198, and eEF2. Each is linked with SOX12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX12-to-partner and partner-to-SOX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SOX12-low versus SOX12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX12→partner) and Y-score (partner→SOX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.217	+3.169	.049	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.998	+3.169	.002	.020	3	1
UCEC	eEF2 →	+0.583	+3.169	.002	.020	2	1
UCEC	MEK1 →	+0.541	+3.000	.007	.036	2	1
UCEC	p62 Lck ligand →	+0.590	+3.169	<.001	.020	1	1
UCEC	ARID1A →	-0.215	-3.162	.031	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Lck by SOX12 expression — UCEC

Explore this box plot interactively →