SOX10

Across TCGA patient cohorts, SOX10 protein abundance is significantly associated with the RNA expression of many other genes, with 5,944 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SOX10-associated genes across cancer lineages are TAFA4, QKI, and PLPPR1. Each is linked with SOX10 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX10-to-partner and partner-to-SOX10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX10 versus TAFA4 in GBM, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX10→partner) and Y-score (partner→SOX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TAFA4 →	+0.398	+0.873	<.001	<.001	3	3
HNSC	QKI →	+0.731	+2.923	.007	.009	2	3
GBM	PLPPR1 →	+1.675	+0.978	<.001	<.001	3	2
BRCA	ZNF462 →	+1.025	+1.800	<.001	<.001	3	2
GBM	SLC5A11 →	+1.498	+1.135	<.001	<.001	3	2
HNSC	PAQR8 →	+1.460	+2.923	.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,944 associations by consensus.

SOX10 vs TAFA4 — GBM

Explore this scatter interactively →