SOX10

Across TCGA patient cohorts, SOX10 mutation is significantly associated with the RNA expression of many other genes, with 1,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX10-associated genes across cancer lineages are MTCO3P1, CLCP2, and GAK. Each is linked with SOX10 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX10-to-partner and partner-to-SOX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P1 grouped by SOX10-low versus SOX10-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX10→partner) and Y-score (partner→SOX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTCO3P1 →	+0.105	+4.754	<.001	.003	3	3
COAD	CLCP2 →	+0.251	+3.024	.002	.003	3	3
UCEC	GAK →	+0.314	+3.724	.007	<.001	3	2
UCEC	CDCA2 →	+0.626	+2.600	.009	.006	3	2
UCEC	SPOUT1 →	+0.435	+3.818	<.001	<.001	3	2
UCEC	MPV17L2 →	+0.399	+3.788	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,126 associations by consensus.

MTCO3P1 by SOX10 expression — LUAD

Explore this box plot interactively →