SOX10

Across TCGA patient cohorts, SOX10 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX10-associated genes across cancer lineages are JNK2, Ku80, and Notch1. Each is linked with SOX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX10-to-partner and partner-to-SOX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SOX10-low versus SOX10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX10→partner) and Y-score (partner→SOX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.174	+3.009	.045	.019	3	1
UCEC	Ku80 →	+0.204	+1.598	.048	.044	3	1
UCEC	Notch1 →	+0.181	+2.331	.003	.019	3	1
UCEC	4E-BP1 →	+0.244	+2.999	.039	.035	3	1
UCEC	C-Raf →	+0.149	+2.115	.017	.019	3	1
SKCM	Rb →	+0.210	+2.832	.029	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by SOX10 expression — UCEC

Explore this box plot interactively →