SOX10

Across TCGA cell cohorts, SOX10 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOX10-associated genes across cancer lineages are ACOD1, LGALS13, and RPL10L. Each is linked with SOX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX10-to-partner and partner-to-SOX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACOD1 grouped by SOX10-low versus SOX10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX10→partner) and Y-score (partner→SOX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ACOD1 →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	LGALS13 →	+0.584	+4.384	<.001	.006	3	1
BLOOD_Leukemia	RPL10L →	+0.040	+3.874	<.001	.005	3	1
BLOOD_Leukemia	SLC36A2 →	+0.022	+3.551	<.001	.009	3	1
BLOOD_Leukemia	TMEM207 →	+0.191	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACOD1 by SOX10 expression — BLOOD_Leukemia

Explore this box plot interactively →