Across TCGA patient cohorts, SOX1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX1-associated genes across cancer lineages are ATM, Rad50, and Stathmin. Each is linked with SOX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX1-to-partner and partner-to-SOX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX1→partner) and Y-score (partner→SOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.507	-2.446	.003	.018	3	3
UCEC	Rad50 →	-0.220	-1.678	.018	.023	3	2
COAD	Stathmin →	+0.151	+2.182	.018	.033	3	2
COAD	p38-MAPK_pT180_Y182 →	+0.483	+1.900	.008	.030	3	1
COAD	CD49b →	-0.254	-2.982	.041	.034	3	1
COAD	Chk1_pS345 →	+0.095	+2.182	.040	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

SOX1 survival (RNA) · tumor vs normal (RNA) · all SOX1 data types