Across TCGA pan-cancer cohorts, SOX1-OT RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SOX1-OT’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where SOX1-OT RNA is repressed in tumor relative to normal tissue. In most cancer types SOX1-OT is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.
THCA, COAD, and BRCA are the cancer types where SOX1-OT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX1-OT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.