Across TCGA pan-cancer cohorts, SOWAHB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SOWAHB data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SOWAHB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SOWAHB expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where SOWAHB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	1.000	0.672	.013	24	view →
UCEC	DFS	Median	All	0.959	0.788	.017	16	view →
PDAC	DFS	Tertile	All	0.514	1.000	.013	12	view →
CCRCC	DFS	Median	III,IV	0.783	0.454	.032	3	view →
LUAD	OS	Quartile	All	0.764	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SOWAHB tumor-vs-normal RNA expression · all SOWAHB data types