Across TCGA pan-cancer cohorts, SOWAHB mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SOWAHB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SOWAHB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SOWAHB is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where SOWAHB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOWAHB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.679	<.001	8	view →
CCRCC	All	III,IV	−0.235	<.001	8	view →
LUAD	Female	All	+0.309	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SOWAHB RNA expression & survival · all SOWAHB data types