SOSTDC1

Across TCGA pan-cancer cohorts, SOSTDC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SOSTDC1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SOSTDC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SOSTDC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where SOSTDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.835	0.531	.015	8	view →
CCRCC	DFS	Median	All	0.916	0.151	.006	7	view →
LSCC	OS	Median	II,III,IV	0.727	0.898	.021	2	view →
HNSC	DFS	Quartile	III,IV	1.000	0.488	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SOSTDC1–LUAD (OS)

Open the LUAD breakdown →