SOSTDC1

Across TCGA patient cohorts, SOSTDC1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,780 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SOSTDC1-associated genes across cancer lineages are NR1D2, ZHX2, and PTCH1. Each is linked with SOSTDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOSTDC1-to-partner and partner-to-SOSTDC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOSTDC1 versus NR1D2 in LSCC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOSTDC1→partner) and Y-score (partner→SOSTDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NR1D2 →	+0.494	+1.439	.007	.001	3	2
HNSC	ZHX2 →	+1.061	+1.463	.001	.007	3	2
LSCC	PTCH1 →	+1.080	+1.208	<.001	.006	3	2
LSCC	PSPC1P1 →	+1.778	+1.318	<.001	.001	3	2
HNSC	RTN3P1 →	+1.842	+1.609	<.001	.003	3	2
LSCC	TNRC6B →	+0.399	+1.208	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,780 associations by consensus.

SOSTDC1 vs NR1D2 — LSCC

Explore this scatter interactively →