SOSTDC1

Across TCGA patient cohorts, SOSTDC1 mutation is significantly associated with the RNA expression of many other genes, with 621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOSTDC1-associated genes across cancer lineages are RNU6-217P, MIR105-2, and TSPY4. Each is linked with SOSTDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOSTDC1-to-partner and partner-to-SOSTDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-217P grouped by SOSTDC1-low versus SOSTDC1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOSTDC1→partner) and Y-score (partner→SOSTDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-217P →	+0.198	+7.930	<.001	.008	3	1
LUAD	MIR105-2 →	+0.441	+7.930	<.001	.008	3	1
LUAD	TSPY4 →	+0.069	+7.930	<.001	.008	3	1
LUAD	RNA5SP272 →	+0.347	+7.930	<.001	.008	3	1
UCEC	IGLV2-8 →	+2.317	+3.584	<.001	.003	3	1
UCEC	UBC →	+0.485	+3.201	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 621 associations by consensus.

RNU6-217P by SOSTDC1 expression — LUAD

Explore this box plot interactively →