SOSTDC1

Across TCGA patient cohorts, SOSTDC1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOSTDC1-associated genes across cancer lineages are EGFR_pY1068, Ku80, and FoxM1. Each is linked with SOSTDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOSTDC1-to-partner and partner-to-SOSTDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SOSTDC1-low versus SOSTDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOSTDC1→partner) and Y-score (partner→SOSTDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.328	-3.000	.012	.036	3	1
UCEC	Ku80 →	+0.322	+3.335	.009	.005	3	1
UCEC	FoxM1 →	+0.304	+3.321	.025	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

EGFR_pY1068 by SOSTDC1 expression — UCEC

Explore this box plot interactively →