Across TCGA patient cohorts, SOST RNA expression is significantly associated with the go_rna of many other GO terms, with 6,867 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SOST-associated GO terms across cancer lineages are Establishment of planar polarity of embryonic epithelium, Establishment of planar polarity involved in neural tube closure, and Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Each is linked with SOST in more than 16 cancer types. Because this analysis shows association rather than direction, both SOST-to-partner and partner-to-SOST results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOST→partner) and Y-score (partner→SOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Establishment of planar polarity of embryonic epithelium →	+0.110	+1.201	<.001	<.001	3	16
ESCA	Establishment of planar polarity involved in neural tube closure →	+0.103	+1.028	<.001	<.001	3	15
STAD	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.046	+0.118	<.001	.002	3	15
STAD	Formation of primary germ layer →	+0.055	+0.205	<.001	<.001	2	16
SCLC	Collagen fibril organization →	+0.124	+0.259	.003	.009	1	17
PAAD	Peptidyl-lysine oxidation →	+0.079	+0.246	<.001	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,867 associations by consensus.

Exploration

SOST survival (RNA) · tumor vs normal (RNA) · all SOST data types