SOST

Across TCGA patient cohorts, SOST protein abundance is significantly associated with the RNA expression of many other genes, with 1,214 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SOST-associated genes across cancer lineages are SYNGR1, TXN2, and ABHD4. Each is linked with SOST in more than 1 cancer types. Because this analysis shows association rather than direction, both SOST-to-partner and partner-to-SOST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOST versus SYNGR1 in LSCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOST→partner) and Y-score (partner→SOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYNGR1 →	+0.774	+1.439	<.001	.001	3	1
LSCC	TXN2 →	+0.422	+1.146	<.001	.001	3	1
LSCC	ABHD4 →	+0.627	+1.421	<.001	<.001	3	1
LSCC	TCL1A →	-0.681	-1.151	.002	.002	3	1
LSCC	PLCB4 →	+1.534	+1.470	<.001	<.001	3	1
LSCC	JAG1 →	+0.965	+1.220	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,214 associations by consensus.

SOST vs SYNGR1 — LSCC

Explore this scatter interactively →