SOST

Across TCGA cell cohorts, SOST RNA expression is significantly associated with the go_rna of many other GO terms, with 728 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SOST-associated GO terms across cancer lineages are Doxorubicin metabolic process, Sesquiterpenoid metabolic process, and Polyketide metabolic process. Each is linked with SOST in more than 5 cancer types. Because this analysis shows association rather than direction, both SOST-to-partner and partner-to-SOST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Doxorubicin metabolic process grouped by SOST-low versus SOST-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOST→partner) and Y-score (partner→SOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Doxorubicin metabolic process →	+0.420	+3.838	.001	.007	3	5
OESOPHAGUS	Sesquiterpenoid metabolic process →	+0.293	+2.229	.002	.001	2	6
LUNG_NSCLC_LUSC	Polyketide metabolic process →	+0.420	+3.838	.001	.007	3	5
BLOOD_Leukemia	Cellular response to jasmonic acid stimulus →	+0.950	+0.010	<.001	.001	2	6
BLOOD_Leukemia	Response to jasmonic acid →	+0.950	+0.010	<.001	.001	2	6
LUNG_NSCLC_LUAD	Isoprenoid catabolic process →	+1.099	+0.333	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 728 associations by consensus.

Doxorubicin metabolic process by SOST expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →