SOST

Across TCGA cell cohorts, SOST mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOST-associated genes across cancer lineages are SSMEM1, C16orf96, and USP17L19. Each is linked with SOST in more than 1 cancer types. Because this analysis shows association rather than direction, both SOST-to-partner and partner-to-SOST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by SOST-low versus SOST-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOST→partner) and Y-score (partner→SOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.022	+3.029	.003	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
LUNG_NSCLC_LUAD	USP17L19 →	+0.005	+5.266	<.001	.001	3	1
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.461	+3.252	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SSMEM1 by SOST expression — LARGE_INTESTINE

Explore this box plot interactively →