SOS1

Across TCGA pan-cancer cohorts, SOS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SOS1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SOS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SOS1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, GBM, and UCEC are the cancer types where SOS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.999	0.882	.005	11	view →
GBM	DFS	Quartile	All	0.206	0.521	.001	11	view →
UCEC	OS	Median	II,III,IV	0.666	1.000	.025	8	view →
CCRCC	DFS	Median	IV	0.233	1.000	.008	6	view →
PDAC	DFS	Median	III,IV	0.297	0.724	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SOS1–LSCC (DFS)

Open the LSCC breakdown →