SOS1

Across TCGA pan-cancer cohorts, SOS1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SOS1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SOS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SOS1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where SOS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.378	<.001	12	view →
PDAC	All	II,III,IV	+0.308	<.001	6	view →
LSCC	All	II,III,IV	+0.109	<.001	5	view →
COAD	Male	All	−0.148	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SOS1–CCRCC

Open the CCRCC breakdown →