SOS1

Across TCGA patient cohorts, SOS1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOS1-associated genes across cancer lineages are C-Raf, A-Raf_pS299, and JNK_pT183_Y185. Each is linked with SOS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SOS1-to-partner and partner-to-SOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SOS1-low versus SOS1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS1→partner) and Y-score (partner→SOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C-Raf →	+0.364	+3.472	<.001	.002	3	5
UCEC	A-Raf_pS299 →	-0.095	-1.874	.005	.002	3	3
UCEC	JNK_pT183_Y185 →	-0.098	-1.156	.043	.017	3	3
UCEC	4E-BP1_pT37_T46 →	-0.329	-1.169	.002	.017	3	3
UCEC	Caspase-7-cleavedD198 →	+0.584	+1.604	<.001	.005	3	3
COAD	eEF2 →	+0.393	+2.815	.015	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

C-Raf by SOS1 expression — BLCA

Explore this box plot interactively →