SOS1

Across TCGA cell cohorts, SOS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,384 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SOS1-associated GO terms across cancer lineages are Positive regulation of mRNA catabolic process, Stress granule assembly, and Positive regulation of organelle assembly. Each is linked with SOS1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SOS1-to-partner and partner-to-SOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA catabolic process grouped by SOS1-low versus SOS1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS1→partner) and Y-score (partner→SOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of mRNA catabolic process →	+0.053	+0.569	<.001	<.001	3	19
OESOPHAGUS	Stress granule assembly →	+0.134	+0.836	.003	.002	3	19
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.079	+1.195	<.001	<.001	3	19
SOFT_TISSUE	RNA destabilization →	+0.067	+0.842	<.001	<.001	3	18
STOMACH	Regulation of translational initiation →	+0.091	+1.355	<.001	<.001	3	18
OESOPHAGUS	mRNA destabilization →	+0.073	+0.792	<.001	.001	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,384 associations by consensus.

Positive regulation of mRNA catabolic process by SOS1 expression — SOFT_TISSUE

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