SOS1

Across TCGA cell cohorts, SOS1 mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOS1-associated genes across cancer lineages are C20orf85, C7orf77, and WRAP73. Each is linked with SOS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOS1-to-partner and partner-to-SOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by SOS1-low versus SOS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS1→partner) and Y-score (partner→SOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.026	+4.232	<.001	<.001	3	2
LUNG_NSCLC_LUAD	C7orf77 →	+0.046	+4.662	<.001	.005	3	2
LARGE_INTESTINE	WRAP73 →	+0.618	+3.212	.001	.006	3	2
LARGE_INTESTINE	LAX1 →	+0.106	+3.299	<.001	.004	3	2
LARGE_INTESTINE	TLCD3A →	+0.810	+3.212	.001	.006	3	2
BLOOD_Leukemia	GDF5 →	+0.045	+3.506	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

C20orf85 by SOS1 expression — BLOOD_Leukemia

Explore this box plot interactively →