SOS1

Across TCGA cell cohorts, SOS1 mutation is significantly associated with the mutation status of many other genes, with 4,666 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOS1-associated genes across cancer lineages are RTN4, CASP8, and ANKRD44. Each is linked with SOS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SOS1-to-partner and partner-to-SOS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTN4 grouped by SOS1-low versus SOS1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS1→partner) and Y-score (partner→SOS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RTN4 →	+4.339	+5.303	<.001	<.001	1	5
SKIN	CASP8 →	+3.532	+3.357	.005	.005	1	4
BLOOD_Lymphoma	ANKRD44 →	+4.584	+4.584	.007	.007	1	4
BLOOD_Lymphoma	HSPA2 →	+4.584	+4.584	.007	.007	1	4
BLOOD_Lymphoma	VLDLR →	+5.584	+5.014	.003	.003	1	4
BLOOD_Lymphoma	KAT6B →	+3.169	+4.601	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,666 associations by consensus.

RTN4 by SOS1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →