SORT1

Across TCGA pan-cancer cohorts, SORT1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SORT1 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SORT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SORT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, UCEC, and LGG are the cancer types where SORT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.001	0.667	<.001	30	view →
UCEC	DFS	Median	All	0.972	0.827	.015	12	view →
LGG	OS	Median	All	0.134	0.799	<.001	6	view →
PRAD	DFS	Median	All	0.088	0.774	<.001	6	view →
SKCM	OS	Median	III,IV	0.357	0.709	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SORT1–STAD (OS)

Open the STAD breakdown →