SORT1

Across TCGA pan-cancer cohorts, SORT1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SORT1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SORT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SORT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where SORT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.198	0.887	.024	15	view →
LUAD	DFS	Median	III,IV	0.597	0.864	.042	3	view →
LSCC	OS	Median	II,III,IV	0.914	0.805	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SORT1–CCRCC (DFS)

Open the CCRCC breakdown →