SORT1

Across TCGA patient cohorts, SORT1 protein abundance is significantly associated with the RNA expression of many other genes, with 19,761 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SORT1-associated genes across cancer lineages are ABCD2, MAGI3, and TAF4B. Each is linked with SORT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SORT1-to-partner and partner-to-SORT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SORT1 versus ABCD2 in UCEC, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORT1→partner) and Y-score (partner→SORT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABCD2 →	-1.066	-0.638	<.001	.001	3	4
BRCA	MAGI3 →	+1.019	+0.642	<.001	<.001	3	4
BRCA	TAF4B →	-0.859	-0.476	<.001	<.001	3	4
BRCA	ITGA10 →	+0.633	+0.403	.004	<.001	3	4
BRCA	SLC25A4 →	+0.663	+0.512	.002	<.001	3	4
BRCA	MOAP1 →	+0.595	+0.599	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,761 associations by consensus.

SORT1 vs ABCD2 — UCEC

Explore this scatter interactively →