SORT1

Across TCGA patient cohorts, SORT1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORT1-associated genes across cancer lineages are eIF4E, Rab25, and Caspase-7-cleavedD198. Each is linked with SORT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SORT1-to-partner and partner-to-SORT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SORT1-low versus SORT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORT1→partner) and Y-score (partner→SORT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.196	+1.874	.005	.002	3	2
UCEC	Rab25 →	-0.344	-2.115	.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.727	+2.522	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.308	-3.058	<.001	<.001	3	1
UCEC	EGFR →	-0.154	-2.115	.003	.017	3	1
UCEC	ERK2 →	+0.200	+2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by SORT1 expression — UCEC

Explore this box plot interactively →